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PROGYNOVA (Estradiol Valerate) (estradiol) is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.PROGYNOVA (Estradiol Valerate) is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. PROGYNOVA (Estradiol Valerate) is sometimes used as part of cancer treatment in women and men.PROGYNOVA (Estradiol Valerate) may also be used for other purposes not listed in this medication guide.
PROGYNOVA (Estradiol Valerate) can harm an unborn baby or cause birth defects. Do not use PROGYNOVA (Estradiol Valerate) if you are pregnant. You should not take PROGYNOVA (Estradiol Valerate) if you have abnormal vaginal bleeding, liver disease, breast or uterine cancer, hormone-dependent cancer, a recent history of heart attack or stroke, if you are pregnant, if you have ever had a blood clot (especially in your lung or your lower body), or if you are allergic to any medicines or food dyes. Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you have diabetes, high blood pressure, high cholesterol or triglycerides, if you smoke, or if you are overweight.Long-term PROGYNOVA (Estradiol Valerate) treatment may increase your risk of breast cancer, ovarian cancer, or uterine cancer. Talk with your doctor about your individual risks before using PROGYNOVA (Estradiol Valerate) long-term. Your doctor should check your progress every 3 to 6 months to determine whether you should continue this treatment.Taking progestin while using PROGYNOVA (Estradiol Valerate) may lower your risk of uterine cancer. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using PROGYNOVA (Estradiol Valerate) .PROGYNOVA (Estradiol Valerate) should not be used to prevent heart disease, stroke, or dementia, because this medication may actually increase your risk of developing these conditions.Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using PROGYNOVA (Estradiol Valerate) .
You should not take PROGYNOVA (Estradiol Valerate) if you are allergic to estradiol, or if you have:liver disease; abnormal vaginal bleeding that a doctor has not checked;any type of breast, uterine, or hormone-dependent cancer;a recent history of heart attack or stroke;if you are pregnant;if you have ever had a blood clot (especially in your lung or your lower body); orif you are allergic to any medicines or food dyes.Taking hormones, such as PROGYNOVA (Estradiol Valerate) can increase your risk of blood clots, stroke, or heart attack, especially if you have risk factors such as diabetes, high blood pressure, high cholesterol or triglycerides, smoking, or being overweight.If you have any of these other conditions, your doctor may need to adjust your PROGYNOVA (Estradiol Valerate) dose or order special tests:heart disease;kidney disease; family history of blood clots;a history of jaundice caused by pregnancy or taking hormones;endometriosis;lupus;porphyria;gallbladder disease;underactive thyroid;asthma;epilepsy or other seizure disorder;migraines;low levels of calcium in your blood; orif you have had your uterus removed (hysterectomy).FDA pregnancy category X. PROGYNOVA (Estradiol Valerate) can harm an unborn baby or cause birth defects. Do not use PROGYNOVA (Estradiol Valerate) if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Estradiol can pass into breast milk and may harm a nursing baby. PROGYNOVA (Estradiol Valerate) may also slow breast milk production. You should not breast-feed while you are taking estradiol. PROGYNOVA (Estradiol Valerate) should not be used to prevent heart disease, stroke, or dementia, because this medication may actually increase your risk of developing these conditions.
Take PROGYNOVA (Estradiol Valerate) exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.Long-term PROGYNOVA (Estradiol Valerate) treatment may increase your risk of breast cancer, ovarian cancer, or uterine cancer. Talk with your doctor about your individual risks before using PROGYNOVA (Estradiol Valerate) long-term.Taking progestin while using PROGYNOVA (Estradiol Valerate) may lower your risk of uterine cancer. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using PROGYNOVA (Estradiol Valerate) .Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using PROGYNOVA (Estradiol Valerate) . Your doctor should check your progress every 3 to 6 months to determine whether you should continue this treatment.If you need medical tests or surgery, or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are taking PROGYNOVA (Estradiol Valerate) .
Store PROGYNOVA (Estradiol Valerate) at room temperature away from moisture, heat, and light.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line .Overdose can cause nausea, vomiting, or vaginal bleeding.
Do not smoke while using PROGYNOVA (Estradiol Valerate) . Smoking can increase your risk of blood clots, stroke, or heart attack caused by conjugated estrogens.
Side effects of PROGYNOVA (Estradiol Valerate)
Get emergency medical help if you have any of these signs of an allergic reaction to PROGYNOVA (Estradiol Valerate) : hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using PROGYNOVA (Estradiol Valerate) and call your doctor at once if you have a serious side effect such as:unusual vaginal bleeding (especially if you are past menopause);chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;sudden numbness or weakness, especially on one side of the body;sudden severe headache, confusion, problems with vision, speech, or balance;stabbing chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;pain, swelling, warmth, or redness in one or both legs;nausea, vomiting, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless;a lump in your breast;feeling like you might pass out;pain, swelling, or tenderness in your stomach; orjaundice (yellowing of the skin or eyes).Less serious PROGYNOVA (Estradiol Valerate) side effects may include:mild nausea, vomiting, bloating, stomach cramps;breast pain, tenderness, or swelling;freckles or darkening of facial skin;loss of scalp hair;vaginal itching or discharge; orchanges in your menstrual periods, break-through bleeding.This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Tell your doctor about all other medicines you use, especially:a blood thinner such as warfarin (Coumadin);cimetidine (Tagamet);carbamazepine (Carbatrol, Tegretol);phenobarbital (Luminal, Solfoton);phenytoin (Dilantin);rifampin (Rifadin, Rifater, Rifamate, Rimactane); orritonavir (Norvir);St. John's wort;an antibiotic such as clarithromycin (Biaxin) or erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab); orantifungal medication such as ketoconazole (Extina, Ketozole, Nizoral, Xolegal).This list is not complete and other drugs may interact with PROGYNOVA (Estradiol Valerate) . Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
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